3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-
PLX5622
CAS: 1303420-67-8
Molecular Formula: C21H19F2N5O
3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy- - Names and Identifiers
3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy- - Physico-chemical Properties
| Molecular Formula | C21H19F2N5O |
| Molar Mass | 395.41 |
| Density | 1.364±0.06 g/cm3(Predicted) |
| Solubility | Soluble in DMSO (>25 mg/ml) |
| Appearance | Form solid, color Pale yellow |
| Color | Pale yellow |
| pKa | 13?+-.0.40(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Physical and Chemical Properties | Bioactive PLX5622 is a highly selective CSF-1R inhibitor with IC50 less than 10 nM, and its selectivity for CSF-1R is more than 20 times higher than that of KIT and FLT3. |
| Use | The application PLX5622 is a highly selective, effective oral CSF1R inhibitor that can penetrate the blood-brain barrier with a Ki value of 5.9 nM, which can be used for the elimination of expanded and specific microglia before and during the development of the disease course. PLX5622 has good pharmacological properties. |
| In vivo study | In mice, rats, dogs, and monkeys, PLX5622 has ideal pharmacokinetic properties with brain permeability of about 20%. PLX5622 had low systemic clearance, moderate volume of distribution, and good oral bioavailability (>30%). It is an effective tool to study the dynamics of microglia. PLX5622 can cause the elimination of persistent, specific microglial cells during or prior to the development of Alzheimer's disease pathology. |
3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.529 ml | 12.645 ml | 25.29 ml |
| 5 mM | 0.506 ml | 2.529 ml | 5.058 ml |
| 10 mM | 0.253 ml | 1.265 ml | 2.529 ml |
| 5 mM | 0.051 ml | 0.253 ml | 0.506 ml |
Last Update：2024-01-02 23:10:35
3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy- - Nature
| Solubility | Soluble in DMSO (>25 mg/ml) |
Last Update：2024-04-10 22:29:15
3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy- - Introduction
PLX5622 is an organic compound. The following are some properties, uses, preparation and safety information about the compound:
Nature:
-Appearance: The compound is a solid, usually white crystals.
-chemical formula: C24H18F2N4O
-Molecular weight: 418.42g/mol
-Solubility: Soluble in organic solvents, such as dimethyl sulfoxide and methanol in nitrogen atmosphere.
Use:
-The compound is an intermediate used in the synthesis of drugs. It may have a variety of applications in drug research and development, such as lead compounds or drug candidates for synthetic drugs.
-It can also be used as a catalyst or ligand in organic synthesis.
Preparation Method:
-Since the detailed preparation method of the compound may be patented, it is impossible to provide a specific preparation method. In general, it can be synthesized by an organic synthetic route.
Safety Information:
-For the specific toxicity and safety data of the compound, due to the lack of public information, detailed safety information cannot be provided.
-As with any chemical, the correct laboratory safety practices must be followed when using and operating.
-When using and handling the compound, please refer to the relevant safety data sheet (if any) and follow appropriate safety operations.
Please note that for detailed information on specific compounds, it is best to consult reliable chemical literature or consult a professional chemist.
Nature:
-Appearance: The compound is a solid, usually white crystals.
-chemical formula: C24H18F2N4O
-Molecular weight: 418.42g/mol
-Solubility: Soluble in organic solvents, such as dimethyl sulfoxide and methanol in nitrogen atmosphere.
Use:
-The compound is an intermediate used in the synthesis of drugs. It may have a variety of applications in drug research and development, such as lead compounds or drug candidates for synthetic drugs.
-It can also be used as a catalyst or ligand in organic synthesis.
Preparation Method:
-Since the detailed preparation method of the compound may be patented, it is impossible to provide a specific preparation method. In general, it can be synthesized by an organic synthetic route.
Safety Information:
-For the specific toxicity and safety data of the compound, due to the lack of public information, detailed safety information cannot be provided.
-As with any chemical, the correct laboratory safety practices must be followed when using and operating.
-When using and handling the compound, please refer to the relevant safety data sheet (if any) and follow appropriate safety operations.
Please note that for detailed information on specific compounds, it is best to consult reliable chemical literature or consult a professional chemist.
Last Update：2024-04-09 15:16:35
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Spot supply
Product Name: 1-TERT-BUTYLPIPERIDIN-4-ONE Visit Supplier Webpage Request for quotationCAS: 1303420-67-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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